منابع مشابه
Astroglial gap junctions shape neuronal network activity
Astrocytes, the third element of the tripartite synapse, are active players in neurotransmission. Up to now, their involvement in neuronal functions has primarily been investigated at the single cell level. However, a key property of astrocytes is that they communicate via extensive networks formed by gap junction channels. Recently, we have shown that this networking modulates the moment to mo...
متن کاملNeuronal activity up-regulates astroglial gene expression.
Neuronal gene expression is known to be modulated by functional activity. This modulation is thought to play a key role in determining the differentiation of developing neurons and regulating the operation of mature neurons. Here we describe a regulation of astroglial gene expression by neuronal activity. We report that intense neuronal activity (electrically induced seizures) in rat hippocampu...
متن کاملCarbenoxolone blockade of neuronal network activity in culture is not mediated by an action on gap junctions.
Spontaneous activity in the central nervous system is strongly suppressed by blockers of gap junctions (GJs), suggesting that GJs contribute to network activity. However, the lack of selective GJ blockers prohibits the determination of their site of action, i.e. neuronal versus glial. Astrocytes are strongly coupled through GJs and have recently been shown to modulate synaptic transmission, yet...
متن کاملNeuronal Gap Junctions Are Required for NMDA Receptor - Mediated 1
19 20 21 2 ABSTRACT 22 23 NMDA receptors (NMDAR) play an important role in cell survival versus cell 24 death decisions during neuronal development, ischemia, trauma and epilepsy. 25 Coupling of neurons by electrical synapses (gap junctions) is high or increases in 26 neuronal networks during all these conditions. In the developing CNS, neuronal gap 27 junctions are critical for two different t...
متن کاملGap Junctions in Developing Thalamic and Neocortical Neuronal Networks
The presence of direct, cytoplasmatic, communication between neurons in the brain of vertebrates has been demonstrated a long time ago. These gap junctions have been characterized in many brain areas in terms of subunit composition, biophysical properties, neuronal connectivity patterns, and developmental regulation. Although interesting findings emerged, showing that different subunits are spe...
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ژورنال
عنوان ژورنال: Communicative & Integrative Biology
سال: 2012
ISSN: 1942-0889
DOI: 10.4161/cib.19410